Layanan journal yang disediakan oleh Perpustakaan Universitas Gunadarma
| Judul Artikel | : | EFEK PENANGKAPAN RADIKAL HIDROKSIL SENYAWA BARU TURUNAN 1,5-BIS(4'-HIDROKSI-3'-METOKSIFENIL) 1,4-PENTADIEN-3-ON |
|---|---|---|
| Judul Terbitan | : | SIGMA : Jurnal Sains dan Teknologi |
| ISSN | : | 14105888 |
| Bahasa | : | IND |
| Tempat Terbit | : | Yogyakarta |
| Tahun | : | 0000 |
| Volume | : | Vol. 9 Issue 1 0000 |
| Penerbit | : | LPUSD |
| Frekuensi Penerbitan | : | |
| Penulis | : | Nunung Yuniarti, Agung Endro Nugroho, Lukman Hakim, Enade Perdana Istyastono, Supardjan Amir Margono |
| Abstraksi | : | Potassium salt of 1,5-bis(4'-hydroxy-3'-methoxyphenyl)-1,4-pentadien-3-one, a new derivative of 1,5-bis(4'-hydroxy-3'-methoxyphenyl)-1,4-pentadien-3-one has been synthesized. The compound's activity as hydroxyl radical scavenger was examined using deoxyribose method. The activity was compared to the activities of some anti-inflammatory agents, i.e. 1,5-bis(4'-hydroxy-3'-methoxyphenyl)-1,4-pentadien-3-one, sodium salt of PGV-O, ascorbic acid, sodium diclofenac, and paracetamol. The results showed that potassium salt of 1,5-bis(4'-hydroxy-3'-methoxyphenyl)-1,4-pentadien-3-one did not have hydroxyl radical scavenger activity. Sodium salt of PGV-0 and sodium diclofenac, which are anti-inflammatory agents, did not have hydroxyl radical scavenger activity too. Therefore, if potassium salt of 1,5-bis(4'hydroxy-3'-methoxyphenyl)-1,4-pentadien-3-one has anti-inflammatory activity, the mechanism would not be through hydroxyl radical scavenging. The anti-inflammatory activity of this compound should be verified by another in vitro test, i.e. cyclooxigenase (COX) inhibition test and in vivo method test. |
| Kata Kunci | : | Potassium salt of 1;5-bis(4'-hydroxy-3-methoxyphenyl)-1;4-pentadien-3-one; anti-inflammatory activity; hydroxyl radical scavenger |
| Lokasi | : | p. 57 |
| Terakreditasi | : | belum |