Layanan journal yang disediakan oleh Perpustakaan Universitas Gunadarma
| Judul Artikel | : | Epidermal growth factor polymorphism most prevalent in stage II cervical carcinoma |
|---|---|---|
| Judul Terbitan | : | Universa Medicina |
| ISSN | : | 19073062 |
| Bahasa | : | ENG |
| Tempat Terbit | : | Jakarta |
| Tahun | : | 0000 |
| Volume | : | Vol. 33 Issue 3 0000 |
| Penerbit | : | Medical Faculty, Trisakti University |
| Frekuensi Penerbitan | : | 3 x 1 tahun |
| Penulis | : | Kevin Dominique Tjandraprawira*, Ramdan Panigoro**, Yudi Mulyana Hidayat***, Herman Susanto***, and Edhyana Sahiratmadja |
| Abstraksi | : | BACKGROUND Cervical cancer ranks second among female cancers worldwide and is widely associated with human papilloma virus (HPV) infection. However, HPV infection progression is influenced by various host factors. Epidermal growth factor (EGF) is a host factor important for proper epithelial proliferation and development, and may playa role in cervical cancer progression. A functional A61 G polymorphism in the EGF gene has been hypothesized to alter EGF concentration in vivo with increasing guanine content associated with greater EGF level. However, a map of A61 G polymorphism distribution is not available for any population, including Indonesia. This study aims to determine the distribution of EG F A61 G polymorphism among cervical cancer patients at Dr. Hasan Sadikin General Hospital. METHODS A retrospective cross-sectional study was conducted between July-November 20 I O. Included were 61 cervical cancer patients of various stages at Dr. Hasan Sadikin hospital, who had previously undergone blood sample collection, DNA isolation and finally genotyping for EGF gene using Illumina 8eadXpress®. Chi-square test was used to analyse the data. RESULTS The EGF A61 G polymorphism was exhibited by 88.5% of patients (as genotypes A/G and GIG). The majority of patients with this polymorphism were of moderate severity (FfGO stage II and Ill, 42.6% and 38.1 % respectively). Patients with the polymorphism but with the lightest severity (FIGO stage I) accounted for 22.2% of the population. CONCLUSION EGF A61 G polymorphism affected the majority of cervical cancer patients and that once stratified, the patients showed intermediate severity in terms of their cancerous growth. |
| Kata Kunci | : | Cervical cancer; EGF; A61 G polymorphism |
| Lokasi | : | P192 |
| Terakreditasi | : | belum |