Layanan journal yang disediakan oleh Perpustakaan Universitas Gunadarma
| Judul Artikel | : | Metalloproteinase-9 gene variants and risk for hypertension among ethnic Javanese |
|---|---|---|
| Judul Terbitan | : | Universa Medicina |
| ISSN | : | 19073062 |
| Bahasa | : | ENG |
| Tempat Terbit | : | Jakarta |
| Tahun | : | 0000 |
| Volume | : | Vol. 33 Issue 3 0000 |
| Penerbit | : | Medical Faculty, Trisakti University |
| Frekuensi Penerbitan | : | 3 x 1 tahun |
| Penulis | : | Fitranto Arjadi*, Saefuddin Aziz**, and Alfi Muntafiah |
| Abstraksi | : | BACKGROUND Hypertension is associated with endothelial-dependent vasodilation disorders, due to reduced nitric oxide (NO) availability and excessive angiotensin II (ANG- II) activation. The objective of this study was to determine the association between matrix metallopeptidase 9 (MMP-9) gene polymorphism and hypertension in ethnic Javanese in the 40-80 year age group. METHODS This was a case-control study on 50 PROLANIS patients of family doctors meeting the inclusion criteria and 50 controls without hypertension. Subjects were hypertensive patients with constant systolic arterial pressure of> 140 mmHg and diastolic arterial pressure of >90 mmHg, confirmed in three successive measurements The observed parameters were degree of MMP-9 polymorphism, and NO and ANG-TI levels. Matrix metallopeptidase 9 polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using the Sma! restriction enzyme. MMP-9 polymorph isms were indicated by variation in band patterns. Degree of polymorphism in cases and controls were compared with NO and ANG-II levels in both groups. Data analysis was done using independent t-test, RESULTS The heterozygous (3 band) to normal (2 band) MMP-9 genotype ratio was 3: 1 in hypertensives, but balanced in controls. In hypertensives, heterozygous GA and homozygous AA genotype frequencies were respectively 3.198 and 1.548 times higher than that of the GG genotype (p=0.008 and p=0.726). There was a statistically significant differences of NO and Ang-II levels between cases and controls (p=O.OOO and p=O.OOO; respectively). CONCLUSION Matrix metallopeptidase 9 gene polymorph isms in hypertensive ethnic Javanese are associated with NO and angiotensin II levels. |
| Kata Kunci | : | Hypertension; ethnic Javanese; MMP-9 gene polymorphism; adults |
| Lokasi | : | P213 |
| Terakreditasi | : | belum |