Layanan journal yang disediakan oleh Perpustakaan Universitas Gunadarma
| Judul Artikel | : | Quercetin reduce cardiomyocytes damage in type 2 diabetic rats |
|---|---|---|
| Judul Terbitan | : | Universa Medicina |
| ISSN | : | 19073062 |
| Bahasa | : | ENG |
| Tempat Terbit | : | Jakarta |
| Tahun | : | 0000 |
| Volume | : | Vol. 33 Issue 3 0000 |
| Penerbit | : | Medical Faculty, Trisakti University |
| Frekuensi Penerbitan | : | 3 x 1 tahun |
| Penulis | : | Asri Hendrawati* and Nadhir |
| Abstraksi | : | BACKGROUND Diabetes mellitus (OM) is a group ofmetabolic diseases which are characterized by hyperglycemia, resulting in various complications. A major macrovascular complication ofDM is cardiac failure due to cardiomyopathy. Hyperglycemia increases oxidative stress, so an oxidative-stress reducing therapeutic agent is required, e.g. the antioxidant quercetin. The aim of this study was to assess the effects of quercetin in reducing damage to cardiomyocytes of type 2 diabetic rats. METHODS This research is an experimental study using 40 rats. With simple random allocation, rats were divided into eight groups, then type 2 diabetes mellitus was induced using streptozotocin (5 rats per group). The test material was quercetin given at doses of 5, 20 and 80 mglkgBW/day orally for 4 weeks. Each single dose of quercetin was given in combination with glibenclamide 5 mg/ kgBW /day. After 4 weeks the rats were decapitated and the cardiac tissues taken to quantify the percentage of cell damage after hematoxylin-eosin staining (HE). RESULTS Quercetin at a dose of 80 mglkgBW/day can ,lower cardiomyocyte damage better than quercetin at doses of 5 or 20 mglkgBW/day. A combination of quercetin and glibenclamide can significantly lower levels of cardiomyocyte damage better than quercetin without gJibenclamide (p<0.05). CONCLUSION Quercetin at a dose of 80 mglkgBW/day with or without glibenclamide can lower damage to cardiomyocytes of type 2 diabetic rats. Thus quercetin might serve as a valuable protective agent in cardiovascular inflammatory diseases in diabetic rats. |
| Kata Kunci | : | Quercetin; glibenclamide; cardiomyocytes; type 2 diabetes mellitus; rats |
| Lokasi | : | P185 |
| Terakreditasi | : | belum |