Layanan journal yang disediakan oleh Perpustakaan Universitas Gunadarma
| Judul Artikel | : | Relationship of Angiotensin Converting Enzyme Gene Polymorphism and Hypertension in Yogyakarta, Indonesia |
|---|---|---|
| Judul Terbitan | : | Acta Medica Indonesiana: The Indonesian Journal of Internal Medicine |
| ISSN | : | 01259326 |
| Bahasa | : | IND |
| Tempat Terbit | : | jakarta |
| Tahun | : | 0000 |
| Volume | : | Vol. 42 Issue 4 0000 |
| Penerbit | : | Interna Publishing |
| Frekuensi Penerbitan | : | |
| Penulis | : | Lucky A. Bawazier*, Mochammad Sjabani**, Sofia M. Haryana***, Marsetyawan H.N.E. Soesatyo, Ahmad H. Sadewa |
| Abstraksi | : | Aim: to evaluate the association between ACE gene polymorphism liD and hypertension in Yogyakarta population. Methods: this study is a cross-sectional. Sample was taken by random sampling method from hypertensive, prehypertensve and normotensive subjects; from that were obtained 125 subjects, 97 subjects and 108 subjects, consecutively. ACE gene polymorphism I/D was examined by PCR. Genotype was classified as 11, ID, or DD based on positive or negative insertionldelateion allele. Results: this study shows significant differences of three groups (ages, body mass index (BMf), and family history of hypertension) and total cholesterol level in blood, which tends to have greater value in the hypertension group. Frequency of genotype 11, ID, DD are 85 (68%),39(31.2%), 1(0.8%) in hypertension, 66 (61.1%),38(35.2%),4(3.7%) in normo-tension and 56(57.7%),37 (38.1%),4 (4.1%) in pre-hypertension subject, consecutively. Chi-square analysis shows statistically significant association between ID+DD vs. 11 genotype and hypertension. Multiple logistic regression analysis shows four variables that significantly influence to hypertension, namely ages.family history of hypertension, BMf, and ACE gene polymorphism. Conclusion: ACE ID+DD genotype has significant relationship with hypertension in Melati population, Sleman, Yogyakarta, Indonesia. |
| Kata Kunci | : | hypertension; genetic; ACE; polymorphism; insertionldeletion. |
| Lokasi | : | P192 |
| Terakreditasi | : | sudah |