Layanan journal yang disediakan oleh Perpustakaan Universitas Gunadarma
| Judul Artikel | : | Serum Gastrin Level and Pepsinogen 1/11 Ratio as Biomarker of Helicobacter pylori Chronic Gastritis |
|---|---|---|
| Judul Terbitan | : | Acta Medica Indonesiana: The Indonesian Journal of Internal Medicine |
| ISSN | : | 01259326 |
| Bahasa | : | IND |
| Tempat Terbit | : | jakarta |
| Tahun | : | 0000 |
| Volume | : | Vol. 42 Issue 3 0000 |
| Penerbit | : | Interna Publishing |
| Frekuensi Penerbitan | : | |
| Penulis | : | I Gede Arinton |
| Abstraksi | : | Aim: to find out biomarker as diagnostic tool of H. pylori chronic gastritis. Methods: the design of present study was a diagnostic test and there were 104 subjects with H. pylori chronic gastritis who fulfilled the inclusion and exclusion criteria. The diagnosis of H. pylori chronic gastritis was based on histopathological examination and PCR with ureC primer of the gastric biopsy specimen. In addition, we also performed the examination of serum gastrin, pepsinogen (PG) 1 and PG (pepsinogen) II level. By using analysis of receiver operating characteristic (ROC), an optimal cut off point of serum gastrin, PGI and PG1I level as well as PGIIPGIl ratio was determined. Analysis of bivariate logistic regression was used to determine the involved independent variables and possibilities as biomarkers. Significance level was determined by p value < 0.05. Results: we found optimal cut off points on serum gastrin, PGI and PGIllevel as well as the PGIIPGIl ratio at 5.89 pmollL; 82.5 ~gIL; 6.48 J.1glL and 13.6 respectively. By using the analysis of bivariate logistic regression, we found gastrin level with p = 0.078 (OR 2. 75;95%CI 0.89- 8.45) andPGIIPGIl ratio withp = 0.000 (OR 14. 63;95%CI 3.55-60.63). The opportunity of gastrin level and PGIIPG1I ratio as biomarkers was 0.8 with 47% sensitivity, 83% specificity, 74%PPV, 61%NPV, 65% accuracy, LR+ = 2. 76 and LR- = 0.64. Conclusion: gastrin level of> 5.89 pmollL and PG11 PGIl ratio S 13.6 can be utilized as biomarkers of H. pylori chronic gastritis. |
| Kata Kunci | : | dyspepsia; chronic gastritis; Helicobacter pylori; gastric cancer; polymerase chain reaction; PCR with ureC primer. |
| Lokasi | : | P142 |
| Terakreditasi | : | sudah |