Layanan journal yang disediakan oleh Perpustakaan Universitas Gunadarma
| Judul Artikel | : | The Cholesterol Lowering Effects of Eurycoma longifolia Jack (Tongkat Ali) Root Extract in Male Rats |
|---|---|---|
| Judul Terbitan | : | MAKARA JOURNAL OF HEALTH RESEARCH |
| ISSN | : | 23563664 |
| Bahasa | : | ENG |
| Tempat Terbit | : | JAKARTA |
| Tahun | : | 0000 |
| Volume | : | Vol. 21 Issue 1 0000 |
| Penerbit | : | DIRECTORATE OF RESEARCH AND COMMUNITY ENGAGMENT, UNIVERSITAS INDONESIA |
| Frekuensi Penerbitan | : | 3 X 1 TAHUN |
| Penulis | : | Ghasak G FaisaI1*, Ghazi F Najmuldeerr, Zurainie Abllah3, Ali S Radeef |
| Abstraksi | : | To investigate the effect of Eurycoms longifolia JaCK root extract on serum lipids in rats. Methods: Twenty - Six mature male albino Wistar rats were used in this study. A group of 18 rats were fed a high fat and high cholesterol diet for 4 weeks, after which their lipid profile was compared to the control group, who were kept on a normal diet. The rats were then further divided into three groups, the C group that continued to feed on a high fat and cholesterol diet only , and group A and group B who continued on a a high fat diet with addition of 5 mg/kg and 10 mg/kg of Eurycoma longifolia Jack root extract respectively for 4 weeks. After the 4 week period, the rats lipid profiles were analysed again. Results: Group A and B showed significant total cholesterol reduction when compared to the c group, 140 ± 7.23, 139.63 ± 7.95, 192.14 ± 8.96 mg/dL respectively (p<0.001). The total cholesterol / HDL ratio in group A was 5 however there was a sharp increase in group B to a high risk level of 9.2 indicating a significant drop in HDL levels. The LDL level increased significantly in both group A and B compared to the C group. Conclusions: Eurycoma longifolia Jack root extract is effective in lowering totsl cholesterol, however the dose needs to be adjusted to prevent an excessive decrease in HDL levels. |
| Kata Kunci | : | wistar rats; cholestrol; eurycoma longifolia jack; HDL; LDL |
| Lokasi | : | P25 |
| Terakreditasi | : | belum |